Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.

Methylphosphonate (MP) oligodeoxynucleotides (MPOs) are metabolically stable analogs of conventional DNA containing a methyl group in place of one of the non-bonding phosphoryl oxygens. All 16 possible chiral R(P) MP dinucleotides were synthesized and derivatized for automated oligonucleotide synthe...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Reynolds, M A, Hogrefe, R I, Jaeger, J A, Schwartz, D A, Riley, T A, Marvin, W B, Daily, W J, Vaghefi, M M, Beck, T A, Knowles, S K, Klem, R E, Arnold, L J
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146287/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8948653/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.22.4584
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