Synthesis and thermodynamics of oligonucleotides containing chirally pure R(P) methylphosphonate linkages.

Methylphosphonate (MP) oligodeoxynucleotides (MPOs) are metabolically stable analogs of conventional DNA containing a methyl group in place of one of the non-bonding phosphoryl oxygens. All 16 possible chiral R(P) MP dinucleotides were synthesized and derivatized for automated oligonucleotide synthe...

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Bibliografiska uppgifter
Huvudupphovsmän: Reynolds, M A, Hogrefe, R I, Jaeger, J A, Schwartz, D A, Riley, T A, Marvin, W B, Daily, W J, Vaghefi, M M, Beck, T A, Knowles, S K, Klem, R E, Arnold, L J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1996
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC146287/
https://ncbi.nlm.nih.gov/pubmed/8948653
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