Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice

Antisense oligonucleotides that are dependent on RNase H for cleavage and subsequent degradation of complementary RNA are being developed as therapeutics. Besides the intended RNA target, such oligonucleotides may also cause degradation of unintended RNA off-targets by binding to partially complemen...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Hagedorn, Peter H, Pontoppidan, Malene, Bisgaard, Tina S, Berrera, Marco, Dieckmann, Andreas, Ebeling, Martin, Møller, Marianne R, Hudlebusch, Heidi, Jensen, Marianne L, Hansen, Henrik F, Koch, Troels, Lindow, Morten
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2018
Sujets:
Chemical Biology and Nucleic Acid Chemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009603/
https://ncbi.nlm.nih.gov/pubmed/29790953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky397
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