Llwytho...
Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice
Antisense oligonucleotides that are dependent on RNase H for cleavage and subsequent degradation of complementary RNA are being developed as therapeutics. Besides the intended RNA target, such oligonucleotides may also cause degradation of unintended RNA off-targets by binding to partially complemen...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Nucleic Acids Res |
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| Prif Awduron: | , , , , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Oxford University Press
2018
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6009603/ https://ncbi.nlm.nih.gov/pubmed/29790953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky397 |
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