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Targeting Repeated Regions Unique to a Gene Is an Effective Strategy for Discovering Potent and Efficacious Antisense Oligonucleotides

Well-validated strategies for discovering potent and efficacious antisense oligonucleotides are central to realize the full therapeutic potential of RNA therapy. In this study, we focus on RNA targets where the same sequence of 16–20 nt is found in several regions across the RNA, and not in any othe...

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Bibliografski detalji
Izdano u:Mol Ther Nucleic Acids
Glavni autori: Pedersen, Lykke, Hagedorn, Peter, Vikeså, Jonas, Karlsen, Signe Tang, Særmark, Pia, Koch, Troels, Lindow, Morten
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6921215/
https://ncbi.nlm.nih.gov/pubmed/31846799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.10.040
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