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Managing the sequence-specificity of antisense oligonucleotides in drug discovery

All drugs perturb the expression of many genes in the cells that are exposed to them. These gene expression changes can be divided into effects resulting from engaging the intended target and effects resulting from engaging unintended targets. For antisense oligonucleotides, developments in bioinfor...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Hagedorn, Peter H., Hansen, Bo R., Koch, Troels, Lindow, Morten
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389529/
https://ncbi.nlm.nih.gov/pubmed/28426096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx056
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