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Managing the sequence-specificity of antisense oligonucleotides in drug discovery

All drugs perturb the expression of many genes in the cells that are exposed to them. These gene expression changes can be divided into effects resulting from engaging the intended target and effects resulting from engaging unintended targets. For antisense oligonucleotides, developments in bioinfor...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Hagedorn, Peter H., Hansen, Bo R., Koch, Troels, Lindow, Morten
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389529/
https://ncbi.nlm.nih.gov/pubmed/28426096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx056
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