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The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (k(cat)/K(m)) of CK1α
The serine/threonine protein kinase casein kinase 1α (CK1α) functions as a negative regulator of Wnt signaling, phosphorylating β-catenin at serine 45 (P–S45) to initiate its eventual ubiquitin-mediated degradation. We previously showed that the repurposed, FDA-approved anthelminthic drug pyrvinium...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6942998/ https://ncbi.nlm.nih.gov/pubmed/31820934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00891 |
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