Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors

Constitutive WNT activity drives the growth of various human tumors, including nearly all colorectal cancers (CRCs). Despite this prominence in cancer, no WNT inhibitor is currently approved for use in the clinic largely due to the small number of druggable signaling components in the WNT pathway an...

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Vydáno v:Sci Signal
Hlavní autoři: Li, Bin, Orton, Darren, Neitzel, Leif R., Astudillo, Luisana, Shen, Chen, Long, Jun, Chen, Xi, Kirkbride, Kellye C., Doundoulakis, Thomas, Guerra, Marcy L., Zaias, Julia, Fei, Dennis Liang, Rodriguez-Blanco, Jezabel, Thorne, Curtis, Wang, Zhiqiang, Jin, Ke, Nguyen, Dao M., Sands, Laurence R., Marchetti, Floriano, Abreu, Maria T., Cobb, Melanie H., Capobianco, Anthony J., Lee, Ethan, Robbins, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555225/
https://ncbi.nlm.nih.gov/pubmed/28655862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aak9916
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