The CK1α Activator Pyrvinium Enhances the Catalytic Efficiency (k(cat)/K(m)) of CK1α

The serine/threonine protein kinase casein kinase 1α (CK1α) functions as a negative regulator of Wnt signaling, phosphorylating β-catenin at serine 45 (P–S45) to initiate its eventual ubiquitin-mediated degradation. We previously showed that the repurposed, FDA-approved anthelminthic drug pyrvinium...

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Gepubliceerd in:Biochemistry
Hoofdauteurs: Shen, Chen, Li, Bin, Astudillo, Luisana, Deutscher, Murray P., Cobb, Melanie H., Capobianco, Anthony J., Lee, Ethan, Robbins, David J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942998/
https://ncbi.nlm.nih.gov/pubmed/31820934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00891
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