Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT‐targeted therapy

The major cellular antioxidant glutathione (GSH) protects cancer cells from oxidative damage that can lead to the induction of ferroptosis, an iron‐dependent form of cell death triggered by the aberrant accumulation of lipid peroxides. Inhibitors of the cystine‐glutamate antiporter subunit xCT, whic...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Sci
Hauptverfasser: Otsuki, Yuji, Yamasaki, Juntaro, Suina, Kentaro, Okazaki, Shogo, Koike, Naoyoshi, Saya, Hideyuki, Nagano, Osamu
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6942438/
https://ncbi.nlm.nih.gov/pubmed/31692172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14224
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