Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

The cystine-glutamate antiporter subunit xCT suppresses iron-dependent oxidative cell death (ferroptosis) and is therefore a promising target for cancer treatment. Given that cancer cells often show resistance to xCT inhibition resulting in glutathione (GSH) deficiency, however, we here performed a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Okazaki, Shogo, Shintani, Subaru, Hirata, Yuki, Suina, Kentaro, Semba, Takashi, Yamasaki, Juntaro, Umene, Kiyoko, Ishikawa, Miyuki, Saya, Hideyuki, Nagano, Osamu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6173468/
https://ncbi.nlm.nih.gov/pubmed/30333913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26112
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