The role of mutations at codons 32, 47, 54, and 90 in HIV-1 protease flap dynamics

Treatment of Human Immunodeficiency Virus remains challenging due to the emergence of drug resistant strains under the selective pressure produced by standard anti-retroviral therapy. To explore the structural mechanisms of drug resistance, we performed 40 ns molecular dynamics simulations on three...

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Detalhes bibliográficos
Publicado no:Discoveries (Craiova)
Main Authors: Chordia, Poorvi, Dewdney, Tamaria G., Keusch, Bradley, Kuiper, Benjamin D., Ross, Kyla, Kovari, Iulia A., MacArthur, Rodger, Salimnia, Hossein, Kovari, Ladislau C.
Formato: Artigo
Idioma:Inglês
Publicado em: Applied Systems srl 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941557/
https://ncbi.nlm.nih.gov/pubmed/32309558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15190/d.2014.19
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