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Methods for the expression, purification, and crystallization of histone deacetylase 6–inhibitor complexes
Histone deacetylase (HDAC) isozymes modulate numerous regulatory signals and pathways in biological systems, hence serving as targets for drug design. For example, HDAC6 is the cytosolic tubulin deacetylase and its inhibition compromises microtubule dynamics, leading to cancer cell cycle arrest and...
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| Pubblicato in: | Methods Enzymol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6941440/ https://ncbi.nlm.nih.gov/pubmed/31606087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2019.06.028 |
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