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Repeat-associated non-AUG (RAN) translation mechanisms running into focus for GGGGCC-repeat associated ALS/FTD.

Many human diseases are associated with the expansion of repeat sequences within the genes. It has become clear that expressed disease transcripts bearing such long repeats can undergo translation, even in the absence of a canonical AUG start codon. Termed “RAN translation” for repeat associated non...

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Vydáno v:Prog Neurobiol
Hlavní autoři: Goodman, Lindsey D., Bonini, Nancy M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941355/
https://ncbi.nlm.nih.gov/pubmed/31550516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2019.101697
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