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Repeat-associated non-AUG (RAN) translation mechanisms running into focus for GGGGCC-repeat associated ALS/FTD.

Many human diseases are associated with the expansion of repeat sequences within the genes. It has become clear that expressed disease transcripts bearing such long repeats can undergo translation, even in the absence of a canonical AUG start codon. Termed “RAN translation” for repeat associated non...

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Библиографические подробности
Опубликовано в: :Prog Neurobiol
Главные авторы: Goodman, Lindsey D., Bonini, Nancy M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941355/
https://ncbi.nlm.nih.gov/pubmed/31550516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2019.101697
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