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Repeat-associated non-AUG (RAN) translation mechanisms running into focus for GGGGCC-repeat associated ALS/FTD.

Many human diseases are associated with the expansion of repeat sequences within the genes. It has become clear that expressed disease transcripts bearing such long repeats can undergo translation, even in the absence of a canonical AUG start codon. Termed “RAN translation” for repeat associated non...

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Publicado en:Prog Neurobiol
Main Authors: Goodman, Lindsey D., Bonini, Nancy M.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6941355/
https://ncbi.nlm.nih.gov/pubmed/31550516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pneurobio.2019.101697
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