Repeat Associated Non-AUG Translation (RAN Translation) Dependent on Sequence Downstream of the ATXN2 CAG Repeat

Spinocerebellar ataxia type 2 (SCA2) is a progressive autosomal dominant disorder caused by the expansion of a CAG tract in the ATXN2 gene. The SCA2 disease phenotype is characterized by cerebellar atrophy, gait ataxia, and slow saccades. ATXN2 mutation causes gains of toxic and normal functions of...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Scoles, Daniel R., Ho, Mi H. T., Dansithong, Warunee, Pflieger, Lance T., Petersen, Lance W., Thai, Khanh K., Pulst, Stefan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472729/
https://ncbi.nlm.nih.gov/pubmed/26086378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0128769
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