The 3.2 Å Structure of a Bioengineered Variant of Blood Coagulation Factor VIII Indicates Two Conformations of the C2 Domain

BACKGROUND: Coagulation factor VIII represents one of the oldest protein-based therapeutics, serving as an effective hemophilia A treatment for half a century. Optimal treatment consists of repeated intravenous infusions of blood coagulation factor VIII (FVIII) per week for life. Despite overall tre...

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Pubblicato in:J Thromb Haemost
Autori principali: Smith, Ian W., d’Aquino, Anne E., Coyle, Christopher W., Fedanov, Andrew, Parker, Ernest T., Denning, Gabriela, Spencer, H. Trent, Lollar, Pete, Doering, Christopher B., Spiegel, P. Clint
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940532/
https://ncbi.nlm.nih.gov/pubmed/31454152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14621
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