Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Lineage-defining transcription factors (TFs) are compelling targets for leukemia therapy, yet they are among the most challenging proteins to modulate directly with small molecules. We previously used CRISPR screening to identify a salt-inducible kinase 3 (SIK3) requirement for the growth of acute m...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Tarumoto, Yusuke, Lin, Shan, Wang, Jinhua, Milazzo, Joseph P., Xu, Yali, Lu, Bin, Yang, Zhaolin, Wei, Yiliang, Polyanskaya, Sofya, Wunderlich, Mark, Gray, Nathanael S., Stegmaier, Kimberly, Vakoc, Christopher R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940199/
https://ncbi.nlm.nih.gov/pubmed/31697837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001576
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