Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Lineage-defining transcription factors (TFs) are compelling targets for leukemia therapy, yet they are among the most challenging proteins to modulate directly with small molecules. We previously used CRISPR screening to identify a salt-inducible kinase 3 (SIK3) requirement for the growth of acute m...

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Опубликовано в: :Blood
Главные авторы: Tarumoto, Yusuke, Lin, Shan, Wang, Jinhua, Milazzo, Joseph P., Xu, Yali, Lu, Bin, Yang, Zhaolin, Wei, Yiliang, Polyanskaya, Sofya, Wunderlich, Mark, Gray, Nathanael S., Stegmaier, Kimberly, Vakoc, Christopher R.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2020
Предметы:
Myeloid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940199/
https://ncbi.nlm.nih.gov/pubmed/31697837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001576
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