Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep sequencing of 208 serial samples in 16 patients. Relapse-specific somatic alterations were enriched in 12 genes (NR3C1, NR3C2, TP53, N...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Li, Benshang, Brady, Samuel W., Ma, Xiaotu, Shen, Shuhong, Zhang, Yingchi, Li, Yongjin, Szlachta, Karol, Dong, Li, Liu, Yu, Yang, Fan, Wang, Ningling, Flasch, Diane A., Myers, Matthew A., Mulder, Heather L., Ding, Lixia, Liu, Yanling, Tian, Liqing, Hagiwara, Kohei, Xu, Ke, Zhou, Xin, Sioson, Edgar, Wang, Tianyi, Yang, Liu, Zhao, Jie, Zhang, Hui, Shao, Ying, Sun, Hongye, Sun, Lele, Cai, Jiaoyang, Sun, Hui-Ying, Lin, Ting-Nien, Du, Lijuan, Li, Hui, Rusch, Michael, Edmonson, Michael N., Easton, John, Zhu, Xiaofan, Zhang, Jingliao, Cheng, Cheng, Raphael, Benjamin J., Tang, Jingyan, Downing, James R., Alexandrov, Ludmil B., Zhou, Bin-Bing S., Pui, Ching-Hon, Yang, Jun J., Zhang, Jinghui
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940198/
https://ncbi.nlm.nih.gov/pubmed/31697823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002220
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