Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep sequencing of 208 serial samples in 16 patients. Relapse-specific somatic alterations were enriched in 12 genes (NR3C1, NR3C2, TP53, N...

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Pubblicato in:Blood
Autori principali: Li, Benshang, Brady, Samuel W., Ma, Xiaotu, Shen, Shuhong, Zhang, Yingchi, Li, Yongjin, Szlachta, Karol, Dong, Li, Liu, Yu, Yang, Fan, Wang, Ningling, Flasch, Diane A., Myers, Matthew A., Mulder, Heather L., Ding, Lixia, Liu, Yanling, Tian, Liqing, Hagiwara, Kohei, Xu, Ke, Zhou, Xin, Sioson, Edgar, Wang, Tianyi, Yang, Liu, Zhao, Jie, Zhang, Hui, Shao, Ying, Sun, Hongye, Sun, Lele, Cai, Jiaoyang, Sun, Hui-Ying, Lin, Ting-Nien, Du, Lijuan, Li, Hui, Rusch, Michael, Edmonson, Michael N., Easton, John, Zhu, Xiaofan, Zhang, Jingliao, Cheng, Cheng, Raphael, Benjamin J., Tang, Jingyan, Downing, James R., Alexandrov, Ludmil B., Zhou, Bin-Bing S., Pui, Ching-Hon, Yang, Jun J., Zhang, Jinghui
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940198/
https://ncbi.nlm.nih.gov/pubmed/31697823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002220
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