Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep sequencing of 208 serial samples in 16 patients. Relapse-specific somatic alterations were enriched in 12 genes (NR3C1, NR3C2, TP53, N...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Li, Benshang, Brady, Samuel W., Ma, Xiaotu, Shen, Shuhong, Zhang, Yingchi, Li, Yongjin, Szlachta, Karol, Dong, Li, Liu, Yu, Yang, Fan, Wang, Ningling, Flasch, Diane A., Myers, Matthew A., Mulder, Heather L., Ding, Lixia, Liu, Yanling, Tian, Liqing, Hagiwara, Kohei, Xu, Ke, Zhou, Xin, Sioson, Edgar, Wang, Tianyi, Yang, Liu, Zhao, Jie, Zhang, Hui, Shao, Ying, Sun, Hongye, Sun, Lele, Cai, Jiaoyang, Sun, Hui-Ying, Lin, Ting-Nien, Du, Lijuan, Li, Hui, Rusch, Michael, Edmonson, Michael N., Easton, John, Zhu, Xiaofan, Zhang, Jingliao, Cheng, Cheng, Raphael, Benjamin J., Tang, Jingyan, Downing, James R., Alexandrov, Ludmil B., Zhou, Bin-Bing S., Pui, Ching-Hon, Yang, Jun J., Zhang, Jinghui
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6940198/
https://ncbi.nlm.nih.gov/pubmed/31697823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002220
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