Homeostasis and transitional activation of regulatory T cells require c-Myc

Regulatory T cell (T(reg)) activation and expansion occur during neonatal life and inflammation to establish immunosuppression, yet the mechanisms governing these events are incompletely understood. We report that the transcriptional regulator c-Myc (Myc) controls immune homeostasis through regulati...

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Udgivet i:Sci Adv
Main Authors: Saravia, Jordy, Zeng, Hu, Dhungana, Yogesh, Bastardo Blanco, Daniel, Nguyen, Thanh-Long M., Chapman, Nicole M., Wang, Yanyan, Kanneganti, Apurva, Liu, Shaofeng, Raynor, Jana L., Vogel, Peter, Neale, Geoffrey, Carmeliet, Peter, Chi, Hongbo
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6938709/
https://ncbi.nlm.nih.gov/pubmed/31911938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw6443
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