mTOR coordinates transcriptional programs and mitochondrial metabolism of activated T(reg) subsets to protect tissue homeostasis

Regulatory T (T(reg)) cells derived from the thymus (tT(reg)) and periphery (pT(reg)) have central and distinct functions in immunosuppression, but mechanisms for the generation and activation of T(reg) subsets in vivo are unclear. Here, we show that mechanistic target of rapamycin (mTOR) unexpected...

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Vydáno v:Nat Commun
Hlavní autoři: Chapman, Nicole M., Zeng, Hu, Nguyen, Thanh-Long M., Wang, Yanyan, Vogel, Peter, Dhungana, Yogesh, Liu, Xiaojing, Neale, Geoffrey, Locasale, Jason W., Chi, Hongbo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5974344/
https://ncbi.nlm.nih.gov/pubmed/29844370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04392-5
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