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mTOR signaling, Tregs and immune modulation

Foxp3(+) Tregs are central regulators of immune tolerance. As dysregulated Treg responses contribute to disease pathogenesis, novel approaches to target the immunomodulatory functions of Tregs are currently under investigation. mTORC1 and mTORC2 are therapeutic targets of interest. Recent studies re...

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Detalhes bibliográficos
Publicado no:Immunotherapy
Main Authors: Chapman, Nicole M, Chi, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291176/
https://ncbi.nlm.nih.gov/pubmed/25524385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/imt.14.84
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