Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation

Cerebral cavernous malformation (CCM) is a genetic, cerebrovascular disease. Familial CCM is caused by genetic mutations in KRIT1, CCM2 or PDCD10. Notably, disease onset is earlier and more severe in individuals with PDCD10 mutations. Recent studies have shown that lesions arise from excess Mitogen-...

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Bibliografske podrobnosti
izdano v:Sci Transl Med
Main Authors: Tang, Alan T., Sullivan, Katie R., Hong, Courtney C., Goddard, Lauren M., Mahadevan, Aparna, Ren, Aileen, Pardo, Heidy, Peiper, Amy, Griffin, Erin, Tanes, Ceylan, Mattei, Lisa M., Yang, Jisheng, Li, Li, Mericko-Ishizuka, Patricia, Shen, Le, Hobson, Nicholas, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Polster, Sean P., Roedel, Claudia J., Li, Ning, Zhu, Qin, Whitehead, Kevin J., Zheng, Xiangjian, Akers, Amy, Morrison, Leslie, Kim, Helen, Bittinger, Kyle, Lengner, Christopher J., Schwaninger, Markus, Velcich, Anna, Augenlicht, Leonard, Abdelilah-Seyfried, Salim, Min, Wang, Marchuk, Douglas A., Awad, Issam A., Kahn, Mark L.
Format: Artigo
Jezik:Inglês
Izdano: 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937779/
https://ncbi.nlm.nih.gov/pubmed/31776290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw3521
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