A Brain Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease

Cavernous angioma (CA) is a vascular pathology caused by loss of function in one of the 3 CA genes (CCM1, CCM2, and CCM3) that result in rho kinase (ROCK) activation. We investigated a novel ROCK2 selective inhibitor for the ability to reduce brain lesion formation, growth and maturation. We used ge...

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Publicado no:Transl Stroke Res
Main Authors: McKerracher, Lisa, Shenkar, Robert, Abbinanti, Matthew, Cao, Ying, Peiper, Amy, Liao, James K., Lightle, Rhonda, Moore, Thomas, Hobson, Nicholas, Gallione, Carol, Ruschel, Joerg, Koskimäki, Janne, Girard, Romuald, Rosen, Kenneth, Marchuk, Douglas, Awad, Issam
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036327/
https://ncbi.nlm.nih.gov/pubmed/31446620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12975-019-00725-8
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