Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican

Cerebral cavernous malformations (CCMs) form following loss of the CCM protein complex in brain endothelial cells due to increased endothelial MEKK3 signaling and KLF2/4 transcription factor expression, but the downstream events that drive lesion formation remain undefined. Recent studies have revea...

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Publicat a:J Exp Med
Autors principals: Hong, Courtney C., Tang, Alan T., Detter, Matthew R., Choi, Jaesung P., Wang, Rui, Yang, Xi, Guerrero, Andrea A., Wittig, Carl F., Hobson, Nicholas, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Polster, Sean P., Goddard, Lauren M., Ren, Aileen A., Leu, N. Adrian, Sterling, Stephanie, Yang, Jisheng, Li, Li, Chen, Mei, Mericko-Ishizuka, Patricia, Dow, Lukas E., Watanabe, Hideto, Schwaninger, Markus, Min, Wang, Marchuk, Douglas A., Zheng, Xiangjian, Awad, Issam A., Kahn, Mark L.
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537394/
https://ncbi.nlm.nih.gov/pubmed/32648916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200140
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