Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5

Proteolysis of the Glu(441)-Ala(442) bond in the glycosaminoglycan (GAG) β domain of the versican-V1 variant by a disintegrin-like and metalloproteinase domain with thrombospondin type 1 motif (ADAMTS) proteases is required for proper embryo morphogenesis. However, the processing mechanism and the p...

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Main Authors: Foulcer, Simon J., Nelson, Courtney M., Quintero, Maritza V., Kuberan, Balagurunathan, Larkin, Jonathan, Dours-Zimmermann, Maria T., Zimmermann, Dieter R., Apte, Suneel S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183820/
https://ncbi.nlm.nih.gov/pubmed/25122765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.573287
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