Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis

द्वारा Akers, Amy L., Johnson, Eric, Steinberg, Gary K., Zabramski, Joseph M., Marchuk, Douglas A.
प्रकाशित 2009

ADVANCED MAGNETIC RESONANCE IMAGING OF CEREBRAL CAVERNOUS MALFORMATIONS: II. IMAGING OF LESIONS IN MURINE MODELS

द्वारा Shenkar, Robert, Venkatasubramanian, Palamadai N., Wyrwicz, Alice M., Zhao, Jin-cheng, Shi, Changbin, Akers, Amy, Marchuk, Douglas A., Awad, Issam A.
प्रकाशित 2008

Association of cardiovascular risk factors with disease severity in cerebral cavernous malformation type 1 subjects with the common Hispanic mutation

द्वारा Choquet, Hélène, Nelson, Jeffrey, Pawlikowska, Ludmila, McCulloch, Charles E., Akers, Amy, Baca, Beth, Khan, Yasir, Hart, Blaine, Morrison, Leslie, Kim, Helen
प्रकाशित 2013

Polymorphisms in inflammatory and immune response genes associated with cerebral cavernous malformation type 1 severity

द्वारा Choquet, Hélène, Pawlikowska, Ludmila, Nelson, Jeffrey, McCulloch, Charles E., Akers, Amy, Baca, Beth, Khan, Yasir, Hart, Blaine, Morrison, Leslie, Kim, Helen
में प्रकाशित Cerebrovasc Dis (2014)

Cytochrome P450 and matrix metalloproteinase genetic modifiers of disease severity in Cerebral Cavernous Malformation type 1

द्वारा Choquet, Hélène, Trapani, Eliana, Goitre, Luca, Trabalzini, Lorenza, Akers, Amy, Fontanella, Marco, Hart, Blaine L., Morrison, Leslie A., Pawlikowska, Ludmila, Kim, Helen, Retta, Saverio Francesco
में प्रकाशित Free Radic Biol Med (2016)

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

द्वारा McDonald, David A., Shenkar, Robert, Shi, Changbin, Stockton, Rebecca A., Akers, Amy L., Kucherlapati, Melanie H., Kucherlapati, Raju, Brainer, James, Ginsberg, Mark H., Awad, Issam A., Marchuk, Douglas A.
प्रकाशित 2011

Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis

द्वारा McDonald, David A., Shi, Changbin, Shenkar, Robert, Gallione, Carol J., Akers, Amy L., Li, Stephanie, De Castro, Nicholas, Berg, Michel J., Corcoran, David L., Awad, Issam A., Marchuk, Douglas A.
प्रकाशित 2014

Synopsis of Guidelines for the Clinical Management of Cerebral Cavernous Malformations: Consensus Recommendations Based on Systematic Literature Review by the Angioma Alliance Scie...

द्वारा Akers, Amy, Al-Shahi Salman, Rustam, A. Awad, Issam, Dahlem, Kristen, Flemming, Kelly, Hart, Blaine, Kim, Helen, Jusue-Torres, Ignacio, Kondziolka, Douglas, Lee, Cornelia, Morrison, Leslie, Rigamonti, Daniele, Rebeiz, Tania, Tournier-Lasserve, Elisabeth, Waggoner, Darrel, Whitehead, Kevin
में प्रकाशित Neurosurgery (2017)

Brain Vascular Malformation Consortium: Overview, Progress and Future Directions

द्वारा Akers, Amy L., Ball, Karen L., Clancy, Marianne, Comi, Anne M., Faughnan, Marie E., Gopal-Srivastava, Rashmi, Jacobs, Thomas P., Kim, Helen, Krischer, Jeffrey, Marchuk, Douglas A., McCulloch, Charles E., Morrison, Leslie, Moses, Marsha, Moy, Claudia S., Pawlikowska, Ludmilla, Young, William L.
प्रकाशित 2013

EXCEPTIONAL AGGRESSIVENESS OF CEREBRAL CAVERNOUS MALFORMATION DISEASE ASSOCIATED WITH PDCD10 MUTATIONS

द्वारा Shenkar, Robert, Shi, Changbin, Rebeiz, Tania, Stockton, Rebecca A., McDonald, David A., Mikati, Abdul Ghani, Zhang, Lingjiao, Austin, Cecilia, Akers, Amy L., Gallione, Carol J., Rorrer, Autumn, Gunel, Murat, Min, Wang, De Souza, Jorge Marcondes, Lee, Connie, Marchuk, Douglas A., Awad, Issam A.
में प्रकाशित Genet Med (2014)

A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH)

द्वारा Girard, Romuald, Li, Yan, Stadnik, Agnieszka, Shenkar, Robert, Hobson, Nicholas, Romanos, Sharbel, Srinath, Abhinav, Moore, Thomas, Lightle, Rhonda, Shkoukani, Abdallah, Akers, Amy, Carroll, Timothy, Christoforidis, Gregory A, Koenig, James I, Lee, Cornelia, Piedad, Kristina, Greenberg, Steven M, Kim, Helen, Flemming, Kelly D, Ji, Yuan, Awad, Issam A
में प्रकाशित Neurosurgery (2021)

Biomarkers of cavernous angioma with symptomatic hemorrhage

द्वारा Lyne, Seán B., Girard, Romuald, Koskimäki, Janne, Zeineddine, Hussein A., Zhang, Dongdong, Cao, Ying, Li, Yan, Stadnik, Agnieszka, Moore, Thomas, Lightle, Rhonda, Shi, Changbin, Shenkar, Robert, Carrión-Penagos, Julián, Polster, Sean P., Romanos, Sharbel, Akers, Amy, Lopez-Ramirez, Miguel, Whitehead, Kevin J., Kahn, Mark L., Ginsberg, Mark H., Marchuk, Douglas A., Awad, Issam A.
में प्रकाशित JCI Insight (2019)

Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma

द्वारा Polster, Sean P., Sharma, Anukriti, Tanes, Ceylan, Tang, Alan T., Mericko, Patricia, Cao, Ying, Carrión-Penagos, Julián, Girard, Romuald, Koskimäki, Janne, Zhang, Dongdong, Stadnik, Agnieszka, Romanos, Sharbel G., Lyne, Seán B., Shenkar, Robert, Yan, Kimberly, Lee, Cornelia, Akers, Amy, Morrison, Leslie, Robinson, Myranda, Zafar, Atif, Bittinger, Kyle, Kim, Helen, Gilbert, Jack A., Kahn, Mark L., Shen, Le, Awad, Issam A.
में प्रकाशित Nat Commun (2020)

Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial

द्वारा Polster, Sean P, Stadnik, Agnieszka, Akers, Amy L, Cao, Ying, Christoforidis, Gregory A, Fam, Maged D, Flemming, Kelly D, Girard, Romuald, Hobson, Nicholas, Koenig, James I, Koskimäki, Janne, Lane, Karen, Liao, James K, Lee, Cornelia, Lyne, Seán B, McBee, Nichol, Morrison, Leslie, Piedad, Kristina, Shenkar, Robert, Sorrentino, Matthew, Thompson, Richard E, Whitehead, Kevin J, Zeineddine, Hussein A, Hanley, Daniel F, Awad, Issam A
में प्रकाशित Neurosurgery (2019)

Comprehensive transcriptome analysis of cerebral cavernous malformation across multiple species and genotypes

द्वारा Koskimäki, Janne, Girard, Romuald, Li, Yan, Saadat, Laleh, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Lyne, Seán, Avner, Kenneth, Shenkar, Robert, Cao, Ying, Shi, Changbin, Polster, Sean P., Zhang, Dongdong, Carrión-Penagos, Julián, Romanos, Sharbel, Fonseca, Gregory, Lopez-Ramirez, Miguel A., Chapman, Eric M., Popiel, Evelyn, Tang, Alan T., Akers, Amy, Faber, Pieter, Andrade, Jorge, Ginsberg, Mark, Derry, W. Brent, Kahn, Mark L., Marchuk, Douglas A., Awad, Issam A.
में प्रकाशित JCI Insight (2019)

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation

द्वारा Tang, Alan T., Sullivan, Katie R., Hong, Courtney C., Goddard, Lauren M., Mahadevan, Aparna, Ren, Aileen, Pardo, Heidy, Peiper, Amy, Griffin, Erin, Tanes, Ceylan, Mattei, Lisa M., Yang, Jisheng, Li, Li, Mericko-Ishizuka, Patricia, Shen, Le, Hobson, Nicholas, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Polster, Sean P., Roedel, Claudia J., Li, Ning, Zhu, Qin, Whitehead, Kevin J., Zheng, Xiangjian, Akers, Amy, Morrison, Leslie, Kim, Helen, Bittinger, Kyle, Lengner, Christopher J., Schwaninger, Markus, Velcich, Anna, Augenlicht, Leonard, Abdelilah-Seyfried, Salim, Min, Wang, Marchuk, Douglas A., Awad, Issam A., Kahn, Mark L.
में प्रकाशित Sci Transl Med (2019)