Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial

BACKGROUND: More than a million Americans harbor a cerebral cavernous angioma (CA), and those who suffer a prior symptomatic hemorrhage have an exceptionally high rebleeding risk. Preclinical studies show that atorvastatin blunts CA lesion development and hemorrhage through inhibiting RhoA kinase (R...

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Detalhes bibliográficos
Publicado no:Neurosurgery
Main Authors: Polster, Sean P, Stadnik, Agnieszka, Akers, Amy L, Cao, Ying, Christoforidis, Gregory A, Fam, Maged D, Flemming, Kelly D, Girard, Romuald, Hobson, Nicholas, Koenig, James I, Koskimäki, Janne, Lane, Karen, Liao, James K, Lee, Cornelia, Lyne, Seán B, McBee, Nichol, Morrison, Leslie, Piedad, Kristina, Shenkar, Robert, Sorrentino, Matthew, Thompson, Richard E, Whitehead, Kevin J, Zeineddine, Hussein A, Hanley, Daniel F, Awad, Issam A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Research—Human—Study Protocols
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054711/
https://ncbi.nlm.nih.gov/pubmed/30476251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuros/nyy539
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