Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial

BACKGROUND: More than a million Americans harbor a cerebral cavernous angioma (CA), and those who suffer a prior symptomatic hemorrhage have an exceptionally high rebleeding risk. Preclinical studies show that atorvastatin blunts CA lesion development and hemorrhage through inhibiting RhoA kinase (R...

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Bibliografiset tiedot
Julkaisussa:Neurosurgery
Päätekijät: Polster, Sean P, Stadnik, Agnieszka, Akers, Amy L, Cao, Ying, Christoforidis, Gregory A, Fam, Maged D, Flemming, Kelly D, Girard, Romuald, Hobson, Nicholas, Koenig, James I, Koskimäki, Janne, Lane, Karen, Liao, James K, Lee, Cornelia, Lyne, Seán B, McBee, Nichol, Morrison, Leslie, Piedad, Kristina, Shenkar, Robert, Sorrentino, Matthew, Thompson, Richard E, Whitehead, Kevin J, Zeineddine, Hussein A, Hanley, Daniel F, Awad, Issam A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Research—Human—Study Protocols
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054711/
https://ncbi.nlm.nih.gov/pubmed/30476251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuros/nyy539
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