Targeting Regnase-1 programs long-lived effector T cells for cancer therapy

Adoptive cell therapy represents a new paradigm in cancer immunotherapy but can be limited by poor persistence and function of transferred T cells(1). Here, through an in vivo pooled CRISPR-Cas9 mutagenesis screening, we demonstrate that CD8(+) T cells are reprogrammed to long-lived effector cells w...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Wei, Jun, Long, Lingyun, Zheng, Wenting, Dhungana, Yogesh, Lim, Seon Ah, Guy, Cliff, Wang, Yanyan, Wang, Yong-Dong, Qian, Chenxi, Xu, Beisi, Anil, KC, Saravia, Jordy, Huang, Hongling, Yu, Jiyang, Doench, John G., Geiger, Terrence L., Chi, Hongbo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6937596/
https://ncbi.nlm.nih.gov/pubmed/31827283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1821-z
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