Regnase-1 suppresses TCF-1(+) precursor exhausted T-cell formation to limit CAR–T-cell responses against ALL

Chimeric antigen receptor (CAR)–T-cell therapeutic efficacy is associated with long-term T-cell persistence and acquisition of memory. Memory-subset formation requires T-cell factor 1 (TCF-1), a master transcription factor for which few regulators have been identified. Here, we demonstrate using an...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zheng, Wenting, Wei, Jun, Zebley, Caitlin C., Jones, Lindsay L., Dhungana, Yogesh, Wang, Yong-Dong, Mavuluri, Jayadev, Long, Lingyun, Fan, Yiping, Youngblood, Ben, Chi, Hongbo, Geiger, Terrence L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8288655/
https://ncbi.nlm.nih.gov/pubmed/33690816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009309
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