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Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that optimizes the peptide cargo of major histocompatibility class I (MHC-I) molecules and regulates adaptive immunity. It has unusual substrate selectivity for length and sequence, resulting in poorly understood effects on th...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6936583/ https://ncbi.nlm.nih.gov/pubmed/31843903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912070116 |
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