Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

Endoplasmic reticulum aminopeptidase 1 (ERAP1) is an intracellular enzyme that optimizes the peptide cargo of major histocompatibility class I (MHC-I) molecules and regulates adaptive immunity. It has unusual substrate selectivity for length and sequence, resulting in poorly understood effects on th...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Giastas, Petros, Mpakali, Anastasia, Papakyriakou, Athanasios, Lelis, Aggelos, Kokkala, Paraskevi, Neu, Margarete, Rowland, Paul, Liddle, John, Georgiadis, Dimitris, Stratikos, Efstratios
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936583/
https://ncbi.nlm.nih.gov/pubmed/31843903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912070116
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