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Electrostatic steering enables flow-activated von Willebrand Factor to bind platelet glycoprotein, revealed by single-molecule stretching and imaging
Von Willebrand factor (VWF), a large multimeric blood protein, senses changes in shear stress during bleeding and responds by binding platelets to plug ruptures in the vessel wall. Molecular mechanisms underlying this dynamic process are difficult to uncover using standard approaches due to the chal...
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| 發表在: | J Mol Biol |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6936110/ https://ncbi.nlm.nih.gov/pubmed/30797858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.02.014 |
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