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Electrostatic steering enables flow-activated von Willebrand Factor to bind platelet glycoprotein, revealed by single-molecule stretching and imaging

Von Willebrand factor (VWF), a large multimeric blood protein, senses changes in shear stress during bleeding and responds by binding platelets to plug ruptures in the vessel wall. Molecular mechanisms underlying this dynamic process are difficult to uncover using standard approaches due to the chal...

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Publicat a:J Mol Biol
Autors principals: Jiang, Yan, Fu, Hongxia, Springer, Timothy A., Wong, Wesley P.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936110/
https://ncbi.nlm.nih.gov/pubmed/30797858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.02.014
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