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Flow-induced elongation of von Willebrand factor precedes tension-dependent activation
Von Willebrand factor, an ultralarge concatemeric blood protein, must bind to platelet GPIbα during bleeding to mediate hemostasis, but not in the normal circulation to avoid thrombosis. Von Willebrand factor is proposed to be mechanically activated by flow, but the mechanism remains unclear. Using...
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| Izdano u: | Nat Commun |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5567343/ https://ncbi.nlm.nih.gov/pubmed/28831047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00230-2 |
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