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Elongational Flow Induces the Unfolding of von Willebrand Factor at Physiological Flow Rates

The unfolding of von Willebrand Factor (vWF), one of the largest multimeric proteins in our body, has been shown to be a crucial step in the process of blood clotting. Here we show that elongational flows, which appear during vasoconstriction or stenosis, are the primary activation mechanisms of vWF...

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Detalhes bibliográficos
Main Authors: Sing, Charles E., Alexander-Katz, Alfredo
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862189/
https://ncbi.nlm.nih.gov/pubmed/20441731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.01.032
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