c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC). Despite its high expression in immune cells, the effect of c-Cbl on the tumor microenvironment remains poorly understood. Here we demonstrate that c-Cbl alters the tumor microenvironment and sup...

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Publicado en:Sci Rep
Autores principales: Lyle, Chimera, Richards, Sean, Yasuda, Kei, Napoleon, Marc Arthur, Walker, Joshua, Arinze, Nkiruka, Belghasem, Mostafa, Vellard, Irva, Yin, Wenqing, Ravid, Jonathan D., Zavaro, Elias, Amraei, Razie, Francis, Jean, Phatak, Uma, Rifkin, Ian R., Rahimi, Nader, Chitalia, Vipul C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934810/
https://ncbi.nlm.nih.gov/pubmed/31882749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56208-1
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