Haploinsufficiency of Casitas B-Lineage Lymphoma Augments the Progression of Colon Cancer in the Background of Adenomatous Polyposis Coli Inactivation

Casitas B-lineage lymphoma (c-Cbl) is a recently identified ubiquitin ligase of nuclear β-catenin and a suppressor of colorectal cancer (CRC) growth in cell culture and mouse tumor xenografts. We hypothesized that reduction in c-Cbl in colonic epithelium is likely to increase the levels of nuclear β...

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Publicat a:Am J Pathol
Autors principals: Richards, Sean, Walker, Joshua, Nakanishi, Masako, Belghasem, Mostafa, Lyle, Chimera, Arinze, Nkiruka, Napoleon, Marc A., Ravid, Jonathan D., Crossland, Nicholas, Zhao, Qing, Rosenberg, Daniel, Rahimi, Nader, Chitalia, Vipul C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7074366/
https://ncbi.nlm.nih.gov/pubmed/32113662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2019.10.024
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