c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC). Despite its high expression in immune cells, the effect of c-Cbl on the tumor microenvironment remains poorly understood. Here we demonstrate that c-Cbl alters the tumor microenvironment and sup...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lyle, Chimera, Richards, Sean, Yasuda, Kei, Napoleon, Marc Arthur, Walker, Joshua, Arinze, Nkiruka, Belghasem, Mostafa, Vellard, Irva, Yin, Wenqing, Ravid, Jonathan D., Zavaro, Elias, Amraei, Razie, Francis, Jean, Phatak, Uma, Rifkin, Ian R., Rahimi, Nader, Chitalia, Vipul C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934810/
https://ncbi.nlm.nih.gov/pubmed/31882749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56208-1
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