c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC). Despite its high expression in immune cells, the effect of c-Cbl on the tumor microenvironment remains poorly understood. Here we demonstrate that c-Cbl alters the tumor microenvironment and sup...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Lyle, Chimera, Richards, Sean, Yasuda, Kei, Napoleon, Marc Arthur, Walker, Joshua, Arinze, Nkiruka, Belghasem, Mostafa, Vellard, Irva, Yin, Wenqing, Ravid, Jonathan D., Zavaro, Elias, Amraei, Razie, Francis, Jean, Phatak, Uma, Rifkin, Ian R., Rahimi, Nader, Chitalia, Vipul C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934810/
https://ncbi.nlm.nih.gov/pubmed/31882749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56208-1
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