c-Cbl targets PD-1 in immune cells for proteasomal degradation and modulates colorectal tumor growth

Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorectal cancer (CRC). Despite its high expression in immune cells, the effect of c-Cbl on the tumor microenvironment remains poorly understood. Here we demonstrate that c-Cbl alters the tumor microenvironment and sup...

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Udgivet i:Sci Rep
Main Authors: Lyle, Chimera, Richards, Sean, Yasuda, Kei, Napoleon, Marc Arthur, Walker, Joshua, Arinze, Nkiruka, Belghasem, Mostafa, Vellard, Irva, Yin, Wenqing, Ravid, Jonathan D., Zavaro, Elias, Amraei, Razie, Francis, Jean, Phatak, Uma, Rifkin, Ian R., Rahimi, Nader, Chitalia, Vipul C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934810/
https://ncbi.nlm.nih.gov/pubmed/31882749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56208-1
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