c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/β-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation

The proto-oncogene β-catenin drives colorectal cancer (CRC) tumorigenesis. Casitas B-lineage lymphoma (c-Cbl) inhibits CRC tumor growth through targeting nuclear β-catenin by a poorly understood mechanism. In addition, the role of c-Cbl in human CRC remains largely underexplored. Using a novel quant...

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Udgivet i:Am J Pathol
Main Authors: Kumaradevan, Sowmiya, Lee, Shin Yin, Richards, Sean, Lyle, Chimera, Zhao, Qing, Tapan, Umit, Jiangliu, Yilan, Ghumman, Shmyle, Walker, Joshua, Belghasem, Mostafa, Arinze, Nkiruka, Kuhnen, Angela, Weinberg, Janice, Francis, Jean, Hartshorn, Kevan, Kolachalama, Vijaya B., Cifuentes, Daniel, Rahimi, Nader, Chitalia, Vipul C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099425/
https://ncbi.nlm.nih.gov/pubmed/30029779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.05.007
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