c-Cbl mediates the degradation of tumorigenic nuclear β-catenin contributing to the heterogeneity in Wnt activity in colorectal tumors

Despite the loss of Adenomatous Polyposis Coli (APC) in a majority of colorectal cancers (CRC), not all CRCs bear hallmarks of Wnt activation, such as nuclear β-catenin. This underscores the presence of other Wnt regulators that are important to define, given the pathogenic and prognostic roles of n...

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Vydáno v:Oncotarget
Hlavní autoři: Shashar, Moshe, Siwak, Jamaica, Tapan, Umit, Lee, Shin Yin, Meyer, Rosana D., Parrack, Paige, Tan, Josenia, Khatami, Fatemeh, Francis, Jean, Zhao, Qing, Hartshorn, Kevan, Kolachalama, Vijaya B., Rahimi, Nader, Chitalia, Vipul
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342068/
https://ncbi.nlm.nih.gov/pubmed/27661103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12107
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