The c-Cbl Ubiquitin Ligase Regulates Nuclear β-Catenin and Angiogenesis by Its Tyrosine Phosphorylation Mediated through the Wnt Signaling Pathway

Wnt signaling plays important roles in both the tumor-induced angiogenesis and tumorigenesis through the transcriptionally active nuclear β-catenin. Recently, c-Cbl was identified as a unique E3 ubiquitin ligase targeting the active nuclear β-catenin. However, little is known about the molecular mec...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Shivanna, Sowmya, Harrold, Itrat, Shashar, Moshe, Meyer, Rosanna, Kiang, Chrystelle, Francis, Jean, Zhao, Qing, Feng, Hui, Edelman, Elazer R., Rahimi, Nader, Chitalia, Vipul C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4432275/
https://ncbi.nlm.nih.gov/pubmed/25784557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.616623
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