c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/β-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation

The proto-oncogene β-catenin drives colorectal cancer (CRC) tumorigenesis. Casitas B-lineage lymphoma (c-Cbl) inhibits CRC tumor growth through targeting nuclear β-catenin by a poorly understood mechanism. In addition, the role of c-Cbl in human CRC remains largely underexplored. Using a novel quant...

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Bibliografiset tiedot
Julkaisussa:Am J Pathol
Päätekijät: Kumaradevan, Sowmiya, Lee, Shin Yin, Richards, Sean, Lyle, Chimera, Zhao, Qing, Tapan, Umit, Jiangliu, Yilan, Ghumman, Shmyle, Walker, Joshua, Belghasem, Mostafa, Arinze, Nkiruka, Kuhnen, Angela, Weinberg, Janice, Francis, Jean, Hartshorn, Kevan, Kolachalama, Vijaya B., Cifuentes, Daniel, Rahimi, Nader, Chitalia, Vipul C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Investigative Pathology 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6099425/
https://ncbi.nlm.nih.gov/pubmed/30029779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.05.007
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