Haploinsufficiency of Krüppel-Like Factor 4 Promotes Adenomatous Polyposis Coli–Dependent Intestinal Tumorigenesis

The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer. Previous studies showed that the expression of KLF4 was activated by the colorectal cancer tumor suppressor adeno-matous polyposis coli (APC) and that KLF4 repressed the Wnt/β-catenin...

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Detalhes bibliográficos
Main Authors: Ghaleb, Amr M., McConnell, Beth B., Nandan, Mandayam O., Katz, Jonathan P., Kaestner, Klaus H., Yang, Vincent W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373271/
https://ncbi.nlm.nih.gov/pubmed/17671182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1302
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