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Haploinsufficiency of Krüppel-Like Factor 4 Promotes Adenomatous Polyposis Coli–Dependent Intestinal Tumorigenesis
The zinc finger transcription factor Krüppel-like factor 4 (KLF4) is frequently down-regulated in colorectal cancer. Previous studies showed that the expression of KLF4 was activated by the colorectal cancer tumor suppressor adeno-matous polyposis coli (APC) and that KLF4 repressed the Wnt/β-catenin...
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Main Authors: | , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
2007
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2373271/ https://ncbi.nlm.nih.gov/pubmed/17671182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-1302 |
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