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Altered Intestinal Epithelial Homeostasis in Mice with Intestine-Specific Deletion of the Krüppel-Like Factor 4 Gene

The zinc finger transcription factor, Krüppel-like factor 4 (KLF4), is expressed in the post-mitotic, differentiated epithelial cells lining the intestinal tract and exhibits a tumor suppressive effect on intestinal tumorigenesis. Here we report a role for KLF4 in maintaining homeostasis of intestin...

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Autors principals: Ghaleb, Amr M., McConnell, Beth B., Kaestner, Klaus H., Yang, Vincent W.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3022386/
https://ncbi.nlm.nih.gov/pubmed/21070761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.11.001
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