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TDP-43 aggregation inside micronuclei reveals a potential mechanism for protein inclusion formation in ALS
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease with no known etiology. The formation of pathological protein inclusions, including RNA-binding proteins such as TDP-43 and rho guanine nucleotide exchange factor (RGNEF) are a hallmark of ALS. Despite intensi...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6934605/ https://ncbi.nlm.nih.gov/pubmed/31882736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56483-y |
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